Gastrin-secreting cells are located in which region of the stomach?

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Enteroendocrine cells. Gastrin is a hormone produced by these hormone-secreting cells in the stomach, specifically the G cells located mainly in the antral (pyloric) region of the stomach. Parietal cells and Chief cells are exocrine cells that secrete HCl and pepsinogen, respectively, while D cells secrete somatostatin to inhibit gastrin release. So the cells responsible for gastrin production fall under the enteroendocrine category, in the stomach’s antral mucosa.