Intrinsic factor is produced by which type of gastric cell?

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Multiple Choice

Intrinsic factor is produced by which type of gastric cell?

Intrinsic factor is produced by parietal cells, the acid-secreting cells of the gastric mucosa in the fundus and body. These cells release hydrochloric acid and the intrinsic factor, the latter being essential for vitamin B12 absorption in the terminal ileum by forming a B12–IF complex that binds ileal receptors. Chief cells make pepsinogen, not intrinsic factor, while enteroendocrine cells release various hormones and D cells secrete somatostatin, which inhibits acid secretion. So the correct source is the parietal cells.

Intrinsic factor is produced by parietal cells, the acid-secreting cells of the gastric mucosa in the fundus and body. These cells release hydrochloric acid and the intrinsic factor, the latter being essential for vitamin B12 absorption in the terminal ileum by forming a B12–IF complex that binds ileal receptors. Chief cells make pepsinogen, not intrinsic factor, while enteroendocrine cells release various hormones and D cells secrete somatostatin, which inhibits acid secretion. So the correct source is the parietal cells.

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