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Multiple Choice

Name one example of non-phagocytic antigen-presenting cells. Where are they found?

Dendritic cells are professional antigen-presenting cells that specialize in presenting extracellular antigens to T cells. They capture antigens in peripheral tissues, mature, and migrate to lymphoid organs to activate naive CD4+ T cells by displaying peptide fragments on MHC II. Their strategic locations in the skin (where Langerhans cells reside), in lymph nodes, and in the spleen make them ideal for sampling pathogens and initiating adaptive immune responses. While other cells can present antigen, dendritic cells are the most potent and are classically described as non-phagocytic presenters, distinguishing them from macrophages and neutrophils, which are primarily phagocytic.

Dendritic cells are professional antigen-presenting cells that specialize in presenting extracellular antigens to T cells. They capture antigens in peripheral tissues, mature, and migrate to lymphoid organs to activate naive CD4+ T cells by displaying peptide fragments on MHC II. Their strategic locations in the skin (where Langerhans cells reside), in lymph nodes, and in the spleen make them ideal for sampling pathogens and initiating adaptive immune responses. While other cells can present antigen, dendritic cells are the most potent and are classically described as non-phagocytic presenters, distinguishing them from macrophages and neutrophils, which are primarily phagocytic.