Parietal cells indirectly produce stomach acid by pumping which ions into the lumen of the gastric gland?

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Multiple Choice

Parietal cells indirectly produce stomach acid by pumping which ions into the lumen of the gastric gland?

Parietal cells secrete hydrochloric acid into the gastric lumen by actively moving specific ions into the lumen. The key players are hydrogen ions and chloride ions. Hydrogen ions are pumped into the lumen by the H+/K+ ATPase (proton pump) on the apical membrane, while chloride ions are delivered to the lumen to meet the H+ and form HCl. Cl- is brought into the cell from the blood via a basolateral exchanger and then exits into the lumen through apical Cl- channels. This coordinated transport results in the stomach’s acidic environment as H+ and Cl- combine to form hydrochloric acid.

Parietal cells secrete hydrochloric acid into the gastric lumen by actively moving specific ions into the lumen. The key players are hydrogen ions and chloride ions. Hydrogen ions are pumped into the lumen by the H+/K+ ATPase (proton pump) on the apical membrane, while chloride ions are delivered to the lumen to meet the H+ and form HCl. Cl- is brought into the cell from the blood via a basolateral exchanger and then exits into the lumen through apical Cl- channels. This coordinated transport results in the stomach’s acidic environment as H+ and Cl- combine to form hydrochloric acid.

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