What cells in gastric glands release the hormone somatostatin?

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Multiple Choice

What cells in gastric glands release the hormone somatostatin?

Somatostatin in the stomach is released by specialized enteroendocrine cells known as D cells, located in the gastric glands of the gastric mucosa (especially toward the antrum). These cells respond to luminal acidity by secreting somatostatin, which then acts locally to inhibit gastrin release from neighboring G cells and to dampen acid secretion by parietal cells. This creates a negative feedback loop that helps regulate gastric acid production. Other gastric cells have different roles—parietal cells make acid, chief cells produce pepsinogen, and enteroendocrine cells encompass various hormone-secreting cells, but the specific source of somatostatin in the gastric glands is the D cells. (Somatostatin is also produced elsewhere, such as pancreatic delta cells, but in gastric glands it is the D cells.)

Somatostatin in the stomach is released by specialized enteroendocrine cells known as D cells, located in the gastric glands of the gastric mucosa (especially toward the antrum). These cells respond to luminal acidity by secreting somatostatin, which then acts locally to inhibit gastrin release from neighboring G cells and to dampen acid secretion by parietal cells. This creates a negative feedback loop that helps regulate gastric acid production. Other gastric cells have different roles—parietal cells make acid, chief cells produce pepsinogen, and enteroendocrine cells encompass various hormone-secreting cells, but the specific source of somatostatin in the gastric glands is the D cells. (Somatostatin is also produced elsewhere, such as pancreatic delta cells, but in gastric glands it is the D cells.)

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