What cells in the gastric pits of the pyloric antrum produce the hormone gastrin?

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Gastrin is produced by enteroendocrine G cells that line the glands in the stomach’s pyloric antrum. These G cells specialize in releasing gastrin into the bloodstream in response to stimuli like peptides in the chyme, stomach distension, and vagal signaling. Gastrin then acts to stimulate the parietal cells to secrete acid and supports growth of the gastric mucosa. The pyloric antrum is where these G cells reside, making it the region of gastrin production. In contrast, the fundus and body mainly contain parietal and chief cells responsible for acid and enzyme secretion, while the cardia is rich in mucus-secreting glands.