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Multiple Choice

What inactive proenzyme is produced by chief cells?

Chief cells in the stomach release a zymogen form of a protease—that is, an inactive precursor. This inactive form is pepsinogen, which is secreted into the stomach and activated to pepsin in the acidic gastric environment to start protein digestion. The other options don’t fit because pepsin is the active enzyme, not the inactive precursor; lipase and amylase are different digestive enzymes produced elsewhere (such as the pancreas or salivary glands) and are not produced as inactive proenzymes by chief cells.

Chief cells in the stomach release a zymogen form of a protease—that is, an inactive precursor. This inactive form is pepsinogen, which is secreted into the stomach and activated to pepsin in the acidic gastric environment to start protein digestion. The other options don’t fit because pepsin is the active enzyme, not the inactive precursor; lipase and amylase are different digestive enzymes produced elsewhere (such as the pancreas or salivary glands) and are not produced as inactive proenzymes by chief cells.