Which cells release perforins to form pores in target membranes?

Prepare for your Anatomy and Physiology II Exam with our comprehensive exam resources. Utilize flashcards, multiple choice questions with hints, and detailed explanations. Boost your readiness for success!

Multiple Choice

Which cells release perforins to form pores in target membranes?

Perforin-based killing is a hallmark of cytotoxic lymphocytes. Natural killer cells store perforin in their granules and, upon recognizing a stressed or abnormal cell, release it at the contact point with the target. The perforin molecules insert into the target cell membrane and form pores, which allows granzymes to enter the cell and initiate programmed cell death. This mechanism is fast and specific for virus-infected or malignant cells and is a key part of innate-like cytotoxic defense. Other cells listed don’t use this pore-forming cytotoxic pathway—red blood cells and platelets aren’t killer cells, and B cells are geared toward antibody production rather than perforin-mediated killing.

Perforin-based killing is a hallmark of cytotoxic lymphocytes. Natural killer cells store perforin in their granules and, upon recognizing a stressed or abnormal cell, release it at the contact point with the target. The perforin molecules insert into the target cell membrane and form pores, which allows granzymes to enter the cell and initiate programmed cell death. This mechanism is fast and specific for virus-infected or malignant cells and is a key part of innate-like cytotoxic defense. Other cells listed don’t use this pore-forming cytotoxic pathway—red blood cells and platelets aren’t killer cells, and B cells are geared toward antibody production rather than perforin-mediated killing.

More practice questions