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Multiple Choice

Which glands produce mucus in the duodenum in response to arriving chyme?

Brunner’s glands in the duodenal submucosa are the glands that produce mucus when chyme arrives. They secrete an alkaline mucus rich in bicarbonate, which coats and protects the duodenal lining and helps neutralize the acidic chyme coming from the stomach. This is a targeted protective response to acidic contents, whereas gastric glands are in the stomach, pancreatic acini secrete pancreatic juice, and the crypts of Lieberkühn mainly produce intestinal juice with mucus from goblet cells rather than a dedicated mucus-secreting gland in response to chyme.

Brunner’s glands in the duodenal submucosa are the glands that produce mucus when chyme arrives. They secrete an alkaline mucus rich in bicarbonate, which coats and protects the duodenal lining and helps neutralize the acidic chyme coming from the stomach. This is a targeted protective response to acidic contents, whereas gastric glands are in the stomach, pancreatic acini secrete pancreatic juice, and the crypts of Lieberkühn mainly produce intestinal juice with mucus from goblet cells rather than a dedicated mucus-secreting gland in response to chyme.